Yohimbe Extract, the Raw Material for the Efficient Treatment of Sexual Dysfunction

Yohimbine extract, yohimbine as the symbolic ingredient, is derived from dried bark of African natural plant Corynante Yohimbe. Corynante Yohimbe is an evergreen tree, which is native to Cameroon, Gabon and Congo of southwestern Nigeria. The bark can be used for medicinal purposes. And Africans have processed this plant into herbal Viagra.

Specification: yohimbine 8%, 10% (dark red brown powder); yohimbine HCL 98% (white powder)

Yohimbine HCL is a form of acidification based on 98% yohimbine for better preservation. As it is difficult for alkaloids to exist stably in the case of high purity, so yohimbine HCL 98% will benefit the product storage and transportation and increase its solubility in water, thus it will be better utilized. Currently, the majority of finished Yohimbine extract is not produced in China but in India and the extracting raw materials are from in Africa.

Conventional process:
Stripping the barks, slicing and drying them, smashing the raw materials, putting into pot, adding 12 times amount of 60% ethanol, reflux extraction for 3 times with temperature controlled between 65 ℃ and 85 ℃, the extraction time of 3 hours, 2 hours, 1 hour respectively, filtering the filtrate, merging the filtrate for the 3 times, decompressing and condensing into the extractum with the relative density of 1.10-1.20 (at room temperature), spray drying, destroying into 80 mesh powder, entering warehouse after packing and testing, then the yohimbine extract will be obtained. For high content of yohimbine HCL 98%, extraction, chromatography, crystallization and other processes are further required to achieve the purity of 98%.

Physical properties:
Melting point: 288 ℃-290 ℃, optical rotation: +100 °, easily soluble in chloroform, soluble in methanol, ethanol, slightly soluble in water.
Shelf life: Two years
Preservation: Place it in a cool, dry, dark environment to avoid high temperature.

Mechanism of action:
Yohimbine HCL will increase penile blood flow and raise the formation of nitrous oxide through expanding the penile artery for engorgement and erection, as well as sexual function enhancement. It is known as the pure plant product for the treatment of erectile dysfunction.
In addition, Yohimbine HCL can generate psychological excitement, improving sexual desire. Taking a small amount, perineum could be swelling, stimulating the spinal cord erection center and enhancing sexual function.

The clinical efficacy:
Clinical single dose of yohimbine extract is used for the treatment of various types of male impotence and sexual dysfunction, realizing easier, harder erection in longer duration. This natural plant extract can replace many therapeutic incompetent prescription drugs and equipment with little side effects.
Yohimbine extract can expand the vascular smooth muscle, reduce the sympathetic nervous tension, and increased penile cavernous sinus blood flow through the expansion of the penile artery. Some older people found that the blood is hard to reach the penis. And good blood flow is an inevitable condition for maintaining erections, and yohimbine extract is easier to achieve it.
Erecting the penis, exciting the central sympathetic nervous, improving the quality of life, and maintaining men in a good state.
In addition, yohimbine extract is also suitable for mental, neurological, vascular and diabetic impotence, to relieve sexual dysfunction caused by stress, tension and fatigue, and to increase the body energy supply.

Precautions:
After taking yohimbine products, you may feel temporary mild dizziness, dry mouth, palpitations, abdominal discomfort and other symptoms, which will generally disappear. Please don’t worry.
Do not take it when you suffer from these diseases: anxiety, chest pain, depression, diabetes, heart disease, high blood pressure, kidney disease, liver disease,  post-traumatic stress disorder (PTSD), prostate problem, and schizophrenia.
Do not take it with these drugs: antidepressants and tricyclic antidepressants (heart problem risk), clonidine (hypertension risk) Guanabenze (reduced effectiveness of yohimbine products), hypertensive drug therapy (blood pressure raise risk), stimulants (heart problem risk).

In addition, do not take with these foods and supplements:
these foods and supplements are also contraindicated: any herbal supplements containing caffeine (increased blood pressure risk)，any supplements containing ephedra (increased blood pressure risk), foods that contain tyramine (aged cheese, fermented meats, red wines, etc.), foods that narrow blood vessels (chocolate, coffee, cola, overripe fava beans and tea).
Take it cautiously, then you will experience the unprecedented effect. Of course, if necessary, please consult a doctor if you can take it or not.

Application:
At present, Yohimbine extract is mainly used for male sexual dysfunction or enhance sexual desire. Since it is derived from herbal extracts, not affecting the health of human body with strong effect, it is the best raw materials of health care products, including health wine, medicine nad injection etc.

Xi'an Pincredit Bio-tech Co.,Ltd has achieved a long-term strategic cooperation with international Yohimbine bark purchase and extracting enterprises, importing the third-party certified Yohimbine extract to meet the global needs with reliable quality and stable supply. Welcome to have your advice and procurement.

Gynostemma Pentaphyllum Extract as Raw Material of Anti-hyperlipidemia

Gynostemma pentaphyllum extract, a raw material of traditional Chinese hypolipidemic, is derived from the dry whole herb ethanol extract of cucurbitaceae plant gynostemma pentaphyllum. Gynostemma pentaphyllum is mainly distributed in Shaanxi, Gansu, Hunan, Hubei, Yunnan, Guangxi and other regions of China. The scholars and experts who study gynostemma pentaphyllum extract consider that gynostemma pentaphyllum has excellent nutritional value and conditioning effect and it should be used and promoted.

The production process of gynostemma pentaphyllum extract:

Adopting the dry whole herb of gynostemma pentaphyllum, selecting and washing, cutting into sections with length of 2 to 4 cm, adding ethanol and reflux extraction for 3 times, filtering and merging the filter liquor, adsorbing and purifying through D101 macroporous resin and LSI-010 desalted resin, recycling the ethanol, condensing into extract, depressing and drying at temperature of 70 centigrade, smashing, sieving, packing, sealing, then gynostemma pentaphyllum extract is obtained.

Gynostemma pentaphyllum, the raw material of gynostemma pentaphyllum extract, has two types of taste, bitter and sweet. The active ingredient of both is gypenoside.

Gypenoside is the main functional components of gynostemma pentaphyllum. Its content is an important index to evaluate the quality of gynostemma pentaphyllum. Gypenoside has a basic skeleton similar to ginsenoside and both have the approximate biological activity and effect. The content of gypenoside will be different due to varieties and environmental factors. We adopt the raw material of gynostemma pentaphyllum extract from the Qinba Mountain Areas of China with the academically recognized highest content of gynostemma pentaphyllum.

Difference between sweet gynostemma pentaphyllum and bitter gynostemma pentaphyllum

Sweet gynostemma pentaphyllum with five leaves has good taste while not obvious health effect. And bitter gynostemma pentaphyllum with seven leaves has poor taste while very high active ingredient. Bitter gynostemma pentaphyllum has higher gypenoside content than sweet one. Therefore, gynostemma pentaphyllum extract is from gynostemma pentaphyllum with five leaves. Once open the package, you will feel the bitter taste.

The effect of gynostemma pentaphyllum extract:

1)Lowering blood pressure and blood fact, preventing and treating cardiovascular diseases.

Gynostemma pentaphyllum extract has the significant reduction in blood viscosity and the adjustment of blood pressure function while preventing micro thrombosis and increasing the tolerance of myocardial cells to hypoxia, protecting the myocardium. As gynostemma pentaphyllum extract will not affect the cerebrovascular blood flow while lowering blood pressure, it is very useful for patients suffering from high blood pressure, cardiovascular spasmodic disease and heart insufficiency.

In addition, gynostemma pentaphyllum will remarkably reduce holesterol (TCH), triglyceride (TG) and low density lipoprotein (LDL), elevate high density lipoprotein (HDL), protect the vessel wall, prevent lipid deposition in the blood vessel wall and arteriosclerosis.

Gynostemma pentaphyllum can achieve the purpose of lowering blood fat by regulate the fatty acids, the waster generated after decomposition of oxygen in the body.

2) Improving immunity, regulating the body's physiological function.

Mangy ingredients of gynostemma pentaphyllum and ginseng are the same. Therefore, there is a saying, “Gynostemma pentaphyllum in North China, ginseng in South China”. They both can enhance immunity. And gynostemma pentaphyllum has more moderate drug properties. For physically weak people, they will not adapt to the strong effect of ginseng, while gynostemma pentaphyllum will not confront this problem.

3) Relieving cough and eliminating sputum

Gynostemma pentaphyllum also has the effect of clearing heat and removing toxicity as well as relieving cough and eliminating sputum. It is clinically used mainly for chronic bronchitis.

4) Anti-cancer and anti-tumor effect

Gynostemma pentaphyllum has the inhibitory effect of the proliferation of cancer cells such as liver cancer, lung cancer, uterine cancer and melanoma sarcoma.

5) Anti-aging

Gynostemma pentaphyllum can inhibit the forming of aging substance in the human body, lipofuscin formation, prolonging cell life and delaying aging.                                                                  

The application of gynostemma pentaphyllum extract

The gynostemma pentaphyllum extract is used as the raw material of medicine and health drinks for lowering blood fat and curing cardiovascular diseases, such as health wine, oral liquid, and condensed juice etc.

Our requirements for gynostemma pentaphyllum extract:

Project                   Requirements

Color                     Yellowish white or pale yellow.

Smell                     Light smell, bitter in taste, no peculiar smell.

Trait                      Dry and uniform powder.

Impurity                No visible exogenous impurity to the naked eyes

Xi'an Pincredit Bio-tech Co.,Ltd produces gynostemma pentaphyllum extract with the specification of gypenoside 80%, 98% and 10: 1. Our gynostemma pentaphyllum extract has accurate gypenoside content and authentic taste. As one the most reliable suppliers of gynostemma pentaphyllum extract, our company has been committing to the deep development of gynostemma pentaphyllum. Welcome to have your consultation.

Bitter Melon Extract, Charantin: Natural Raw Material for Reducing Blood Glucose

Bitter melon extract is extracted from the dry fruit of cucurbitaceae hurb bitter melon. The main ingredients are natural active ingredients, such as charantin, polypeptide-k, and elaterin etc. The general specification 2% 5% (UV health food total saponins measurement). The pharmacological effects of charantin are dispelling summerheat to relieve exterior syndrome, improving eyesight and relieve internal heat, diuretic and cooling blood.

The efficacy of bitter melon extract is for auxiliarily decreasing blood sugar. It is often seen in auxiliary hypoglycemic health food. As the number of “three high disease” people (high blood pressure, high blood glucose and hyperlipidemia) is growing year over year, the safety and efficacy requirement for natural hypoglycemic raw materials is also gradually increasing.

The production process:
Harvest in summer and autumn, slice and dry in the shade. Arrange the raw material and put into pot, add 12 times amount of solvent, heat up and reflux extraction for 3 times with temperature controlled reflux extraction, the extraction time is 3 hours, 2 hours, and 1 hour respectively; filter the extracting solution for 3 times, condense the filter liquor under reduced pressure into extractum with the relative density of 1.10-1.20 (room temperature), spray drying, smash to 80 mesh powder, deliver to warehouse after package and measurement, then bitter melon extract is obtained. For high content, the processes of extraction, chromatography and crystallization are needed.

Main effects of bitter melon extract

1. anti-diabetic effect
The steroidal saponins (elaterin, insulin-like peptides and alkaloids) contained in bitter melon give bitter melon hypoglycemic activity. Elaterin stimulates the release of insulin and prevents the formation of glucose in the bloodstream, which may play a significant role in he treatment of diabetes, especially non-insulin-dependent diabetes mellitus. The hypoglycemic function relies on the following substance:
1) Elaterin, the crystalline material obtained from ethanol extract of bitter melon fruit. Elaterin is proved to decrease the blood sugar. Elaterin has the function of pancreas and outer pancreas with the slight spasm and anticholinergic effect.
2) P-insulin (or v-insulin, as it is plant insulin). It is pharmacologically close to bovine insulin with hypoglycemic effect.
2. Antiviral and others effects
Bitter melon extract has been proved to be effective for relieving pain caused by psoriasis, cancer, and neurological complications, delaying the the onset of cataract or retinopathy, inhibiting HIV by destroying virally DNA, and restraining lymphoproliferation as well as macrophages and lymphocyte activity.
3. Good weight loss effect
The bio-active ingredient RPA extracted from the bitter melon extract has a good effect of weight loss. The test shows that taking RPA 2mg-4mg, about 6-12kg fat will be absorbed. And about 3-7kg fat stored in the waist, abdomen, buttocks and thighs will be decomposed.

Precautions
High doses of bitter melon extract can cause diarrhea; For those who suffer from hypoglycemia and insulin-like diabetes, the bitter melon extract should be avoided to use.

Xi'an Pincredit Bio-tech Co.,Ltd has been committing to the development and production of the raw materials for auxiliary hypoglycemia and auxiliary lipid-lowering health care food. We are seamlessly docking with health care food manufacturing enterprises, continuously serving the health of “three high disease” people.

Ginger extract with good stomachic and anti-inflammatory effects

Ginger extract is extracted from the fresh roots of the ginger through supercritical CO2 (SCDE). The main active ingredient: zingiber officinale  gingerol. The 2015 Pharmacopoeia mentioned that zingiber officinale gingerol can stimulate to dispel cold, warm the spleen and stomach and alleviate vomiting, prevent phlegm from forming and stop coughing, detoxicate fish and crab. Zingiber officinale gingerol is divided into different types, namely gingerol, ginger phenol, ginger ketone, gingerdione and gingerdiol etc. 

Production process:

Ginger extract is derived from fresh rhizome of ginger. Harvest in autumn and winter, remove the fibrous roots and sediment, dry to water content of below 5%, smash, then the coarse powder is obtained. Input the raw materials into pot, add 12 times amount of 60% ethanol, reflux and extract for three times with temperature controlled between 65℃ and 85 ℃ and the extraction time is 3 hours, 2 hours, 1 hour respectively, filter the extracting solution, merge the filtrates for the three times and adsorb through macroporous resin, respectively elute with with 70-80% ethanol, 50-60% ethanol, 30-40% ethanol, merge the eluate and stand for 1-3 hours, filter to get crude extract; concentrate the extract to 20-30% of the original volume, stand for 1-2 hours, filter and dry, then the finished ginger extract is obtained. For high content of ginger extract, the processes such as extraction, chromatography, and crystallization are further required.

General specification: zingiber officinale gingerol 5% (HPLC)

Main efficacy:

1. Anti-nausea and anti-vomiting:

Ginger extract is used for preventing nausea caused by chemotherapy and surgical anesthesia, reducing motion sickness due to travel by car or boat, relieving the pregnancy-induced and postoperative nausea and vomiting.

2. Anti-inflammatory

Ginger extract has long been used for reducing inflammatory effects. In fact, many herbalists are currently applying ginger extract to help the treatment of health problems caused by inflammation, such as rthritis, bronchitis and ulcerative colitis. The patients who take ginger extract feel less pain than those taking placebo and require less antalgica.

3. Digestive Tonic Efficacy.

Ginger extract is considered to be a tonic for the digestive tract. It can stimulate digestive function and nourish the intestinal muscles, facilitate the substance to move in the digestive tract and reducing the irritation to the intestinal tract. Ginger extract may protect the stomach from the damage of alcohol and non-steroidal anti-inflammatory drugs (NSAIDs) and may contribute to the prevention of ulcers.

4. Heatstroke prevention and cooling

Ginger extract is also used for relieving the heatstroke symptoms, such as dizziness, chest tightness, and nausea etc.

5. Antioxidant and inhibit tumor

The zingiber officinale gingerol of ginger extract has the effects of antioxidant and free radicals elimination. It can inhibit the tumor, confront the lipofuscin and reduce senile plaques.

Application of ginger extract:

With a variety of biological activity, ginger extract is applied in various fields, including functional drinks, health food, food additives, health care drugs and other fields.

Precautions:

For the prevention or treatment of motion sickness, take 500mg of dry ginger powder extract one to one and a half hours before traveling, and then take 500mg of the extract every two to four hours. Children under six years old should only take half of the adult dose. For the treatment of nausea during pregnancy, the dose for women can be 1 gram per day, but ginger extract should only be used for remission of nausea symptoms rather than as the main drug.  Ginger may have potential for the treatment of nausea caused by anesthesia or chemotherapy, but take it only under the supervision of the physician.

The great effects of salvia miltiorrhiza extract on blood vessels

Salvia miltiorrhiza extract (salvia extract or dan shen extract) is from the dry root and rhizome of salvia miltiorrhiza. The main ingredients include salvianic acid, tanshinone II  A, cryptotanshinone, salvianolic acid B, cryptotanshinone. The general specification: Salvianic acid (5%, 10%), Salvianolic acid B (10%, 50%, 60%).

The extraction process of salvia miltiorrhiza extract:
Harvest in spring and autumn, remove the impurities and residual stems, wash, moisten, cut into thick slices, dry, add solvent and extract twice at 80 centigrade, emerge the extracting solution, filter, condense the filter liquor (60 ℃ ) into clear paste with the relative density of 1.18-1.22 (50 ℃), then the total tanshinones is obtained. Or cool the clear paste and adsorb, elute, and recover it through macroporous resin, then salvianolic acid B is obtained, add ethanol to 70%, heat and stand for 12 hours for decomposition, take the clear liquid, decompress and recover the ethanol, condense it into thick paste, dry it, then salvianic acid is obtained

Physical and chemical indexes of salvia miltiorrhiza extract:

Effects of salvia miltiorrhiza extract:
1.The role of diastolic blood vessels
Salvianic acid can significantly dilate the coronary artery, greatly increasing coronary blood flow, and confront systolic coronary artery effect of morphine and propranol.
2.The role of myocardium protection
Salvianic acid has the effect of narrowing the extent of myocardial infarction and relieving the course of the disease, while decreasing the myocardial ischemia - reperfusion injury, protecting myocardial high energy phosphate compound and mitochondrial membrane.
Salvianolic acid B also has an effect of relieving myocardial ischemia-reperfusion injury.
3.The role of anti-oxidize
The salvianic acid and total tanshinones of salvia miltiorrhiza extract are both good good free radical scavenger. And salvianolic acid B is one of natural product with the strongest antioxidants effect. Pharmacological studies have shown that salvianolic acid B can inhibit platelet aggregation and thrombosis, prolong the survival time of body under hypoxia.
4.The role of anti-atherosclerosis and lipid-lowering
Salvianic acid of salvia miltiorrhiza extract has effects of inhibiting the intracellular endogenous cholesterol, anti-lipid protein oxidation, lowering blood cholesterol, protecting the vascular barrier and preventing lipid deposition and atherosclerosis AS.
Atherosclerosis AS can inhibit LPC to stimulate endothelial cells generate matrix metalloproteinase-2 (MMP-2) for the prevention and treatment of atherosclerosis.

5. The role of cerebral ischemic injury protection
1) The experimental studies have shown that salvianolic acid B can be used with borneol and panax notoginseng for promoting the generation of neovascularization and inhibit vascular permeability increase induced by VEGF (vascular endothelial growth factor). These effects play a very important role in the treatment of ischemic stroke. Salvianolic acid B is considered to be a ideal medicine for anti-cerebral ischemia.
2) Salvianolic acid B has a protective effect on brain inquiry, reducing the area of ischemic area, decreasing the MDA content in brain tissues, alleviating the behavioral disorder caused by cerebral ischemia, improving the memory dysfunction caused by cerebral ischemia.
3) Salvianic acid can significantly reduce the area of cerebral infarction, improve neurological deficits, and reduce brain water content. Salvianic acid can inhibit hypoxia, mitochondrial membrane potential reduction caused by lack of glucose damage, and inhibit the occurrence of apoptosis.
6. The role of anti-inflammatory
It is reported that salvianic acid can significantly inhibit the secretion (P <0.05) of the endotoxin-induced factors with the effects of anti-inflammatory and enhance the immunity. In the clinical application, salvianic acid can be used to improve the survival rate for patients with septic shock.
7.The role of anticoagulant
Salvianic acid can significantly inhibit the accumulation of platelets and greatly increase the mobility of platelet membrane, suggesting that it is effective for coronary heart disease. Salvianic acid can increase the body's fibrinolytic activity, improve blood rheology, and enhancing red blood cell deformability, mediate blood viscosity, and ameliorate microcirculation disturbance of the body organs ( especially heart, liver, lung and pancreas), boosting the rehabilitation of body tissues and adult respiratory distress syndrome and other serious complications.
8.The role of anti-chronic liver lesion
Salvianolic acid B can reduce the liver fibrosis with the effect of anti-lipid peroxidation and anti-chronic liver lesion. In clinical application, it has achieved satisfactory results in the treatment of chronic hepatitis B liver fibrosis. Salvianolic acid B can effect the repair of various chronic liver lesions.
9.The role of anti-tumor and anti-aging
Studies have shown that salvianolic acid B not only can protect the nerve cells via anti-oxidation but also can improve the toxic effects of J3-amyloid on neurons by reducing the release of NO and enhance the secretion of IL-238 from T lymphocyte with the effects of anti-tumor and anti-aging.

 

Clinical application:
Because of the important medicinal value, salvia miltiorrhiza extract is widely used in clinical applications in forms of tables, granules, particles etc. The marketing drugs include Compound Danshen Tables, Danshen Sanqi Granule etc.