Salvia miltiorrhiza extract (salvia extract or dan shen extract) is from the dry root and rhizome of salvia miltiorrhiza. The main ingredients include salvianic acid, tanshinone II A, cryptotanshinone, salvianolic acid B, cryptotanshinone. The general specification: Salvianic acid (5%, 10%), Salvianolic acid B (10%, 50%, 60%).
The extraction process of salvia miltiorrhiza extract:
Harvest in spring and autumn, remove the impurities and residual stems, wash, moisten, cut into thick slices, dry, add solvent and extract twice at 80 centigrade, emerge the extracting solution, filter, condense the filter liquor (60 ℃ ) into clear paste with the relative density of 1.18-1.22 (50 ℃), then the total tanshinones is obtained. Or cool the clear paste and adsorb, elute, and recover it through macroporous resin, then salvianolic acid B is obtained, add ethanol to 70%, heat and stand for 12 hours for decomposition, take the clear liquid, decompress and recover the ethanol, condense it into thick paste, dry it, then salvianic acid is obtained
Physical and chemical indexes of salvia miltiorrhiza extract:
1.The role of diastolic blood vessels
Salvianic acid can significantly dilate the coronary artery, greatly increasing coronary blood flow, and confront systolic coronary artery effect of morphine and propranol.
2.The role of myocardium protection
Salvianic acid has the effect of narrowing the extent of myocardial infarction and relieving the course of the disease, while decreasing the myocardial ischemia - reperfusion injury, protecting myocardial high energy phosphate compound and mitochondrial membrane.
Salvianolic acid B also has an effect of relieving myocardial ischemia-reperfusion injury.
3.The role of anti-oxidize
The salvianic acid and total tanshinones of salvia miltiorrhiza extract are both good good free radical scavenger. And salvianolic acid B is one of natural product with the strongest antioxidants effect. Pharmacological studies have shown that salvianolic acid B can inhibit platelet aggregation and thrombosis, prolong the survival time of body under hypoxia.
4.The role of anti-atherosclerosis and lipid-lowering
Salvianic acid of salvia miltiorrhiza extract has effects of inhibiting the intracellular endogenous cholesterol, anti-lipid protein oxidation, lowering blood cholesterol, protecting the vascular barrier and preventing lipid deposition and atherosclerosis AS.
Atherosclerosis AS can inhibit LPC to stimulate endothelial cells generate matrix metalloproteinase-2 (MMP-2) for the prevention and treatment of atherosclerosis.
5. The role of cerebral ischemic injury protection
1) The experimental studies have shown that salvianolic acid B can be used with borneol and panax notoginseng for promoting the generation of neovascularization and inhibit vascular permeability increase induced by VEGF (vascular endothelial growth factor). These effects play a very important role in the treatment of ischemic stroke. Salvianolic acid B is considered to be a ideal medicine for anti-cerebral ischemia.
2) Salvianolic acid B has a protective effect on brain inquiry, reducing the area of ischemic area, decreasing the MDA content in brain tissues, alleviating the behavioral disorder caused by cerebral ischemia, improving the memory dysfunction caused by cerebral ischemia.
3) Salvianic acid can significantly reduce the area of cerebral infarction, improve neurological deficits, and reduce brain water content. Salvianic acid can inhibit hypoxia, mitochondrial membrane potential reduction caused by lack of glucose damage, and inhibit the occurrence of apoptosis.
6. The role of anti-inflammatory
It is reported that salvianic acid can significantly inhibit the secretion (P <0.05) of the endotoxin-induced factors with the effects of anti-inflammatory and enhance the immunity. In the clinical application, salvianic acid can be used to improve the survival rate for patients with septic shock.
7.The role of anticoagulant
Salvianic acid can significantly inhibit the accumulation of platelets and greatly increase the mobility of platelet membrane, suggesting that it is effective for coronary heart disease. Salvianic acid can increase the body's fibrinolytic activity, improve blood rheology, and enhancing red blood cell deformability, mediate blood viscosity, and ameliorate microcirculation disturbance of the body organs ( especially heart, liver, lung and pancreas), boosting the rehabilitation of body tissues and adult respiratory distress syndrome and other serious complications.
8.The role of anti-chronic liver lesion
Salvianolic acid B can reduce the liver fibrosis with the effect of anti-lipid peroxidation and anti-chronic liver lesion. In clinical application, it has achieved satisfactory results in the treatment of chronic hepatitis B liver fibrosis. Salvianolic acid B can effect the repair of various chronic liver lesions.
9.The role of anti-tumor and anti-aging
Studies have shown that salvianolic acid B not only can protect the nerve cells via anti-oxidation but also can improve the toxic effects of J3-amyloid on neurons by reducing the release of NO and enhance the secretion of IL-238 from T lymphocyte with the effects of anti-tumor and anti-aging.
Because of the important medicinal value, salvia miltiorrhiza extract is widely used in clinical applications in forms of tables, granules, particles etc. The marketing drugs include Compound Danshen Tables, Danshen Sanqi Granule etc.
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