Pueraria Extract Concerns about Your Cardiovascular and Cerebrovascular System

Pueraria extract (also named Kudzu root extract, Kudzuvine root or Ge Gen extract) we often say refers to Pueraria lobata extract, which is extracted from the dry roots of leguminous plant Kudzu Root. Kudzu Root is a classical medicine with a long history.

At present, the pharmacological studies have shown that puerarin and pueraria flavones are the iconic ingredients of Kudzu root extract. The main effects of puerarin include activating blood to remove stasis and the treatment of stroke and hemiplegia, chest swelling and heartache, and ischemic angina. The main effects of pueraria flavones include the treatment of cardiovascular and cerebrovascular diseases such as hypertension, hyperlipidemia, migraine, coronary heart disease, myocardial infarction, angina and so on.

Extraction method:

Dig the pueraria in autumn and winter, cut the fresh plant into thick slices or small pieces, and extract with ethanol.

Conventional process:

Cut dry pueraria into slices, add 10 times of alcohol, heat up and reflux extraction for three times and for 3 hours, 2 hours, 2 hours respectively. Filter and emerge the extracting solution for three times and concentrate the solution to obtain pueraria flavones. Or filter and emerge the extracting solution for three times, then extract the solution with macroporous resin, and concentrate and refine it to obtain puerarin.

 

The main effects of pueraria extract:

1.For cardiovascular and cerebrovascular system

1) For cardiac function and myocardial metabolism

In pueraria extract, puerarin and pueraria flavones can slow down the heart rate, reduce the total peripheral cardiac resistan, reduce myocardial oxygen consumption, improve myocardial efficiency. Puerarin also can significantly reduce ischemia-induced myocardial lactate generation, and infarcted myocardial metabolism.

2) For blood pressure and peripheral blood vessels

In pueraria extract, puerarin and pueraria flavones can decrease the plasma renin activity and angiotensin and decrease the blood pressure.

Puerarin has a significant improvement in microcirculation disorders, increasing the amplitude of microvascular movement and improve the amount of local micro-blood flow;

Pueraria flavones have a significant role in dilating the brain's blood vessels, improving brain microcirculation and peripheral circulation.

It is reported that puerarin can also improve the blocking peripheral unit of retinal vessel, thereby enhancing visual function.

3) For coronary circulation

In pueraria extract, puerarin and pueraria flavones have a significant role in expanding coronary blood vessels, increasing coronary blood flow and decreasing vascular resistance.

2. Other effects

Puerarin has a significant role in lowering blood sugar. The flavonoids compounds can reduce serum cholesterol and reduce oil triglycerides for the treatment of hyperglycemia and hyperlipidemia. In addition, puerarin and pueraria extract are also helpful for alleviating hangover and curing diarrhea.

Pueraria flavones  Pueraria extract

Clinical application:

Pueraria extract is used for the treatment of cardiovascular and cerebrovascular diseases such as hypertension, migraine, coronary heart disease, myocardial infarction, angina pectoris, retinal artery occlusion, retinal vein occlusion, sudden deafness embolism. It can be used to replace traditional Chinese medicine Pueraria.

At the same time, it is widely used in health foods (for alleviating hangover, enlarging breast, delaying female menopause, and complications caused by diabetes, etc.).


Xi'an Pincredit Bio-tech Co.,Ltd is dedicated to the extraction and development of pueraria extract and the extraction of puerarin, pueraria flavones and other other isoflavones. Our general specification of pueraria extract: pueraria flavones 40% UV; puerarin 15% -99%, 99.5%, 99.6%, 99.8%; Extraction method: HPLC; UV.

Pincredit delivered a 3.6-ton Order of Sea Buckthorn Juice Power to South Korea

Good news came again. On April 13, Pincredit team timely delivered a a 3.6-ton Order of sea buckthorn juice power to South Korea. The newly produced sea buckthorn juice power was in authentic orange. When getting close, the rich smell of sea buckthorn emitted. Come to see the new on-site product pictures.

Compared with the general sea buckthorn juice power, Pincredit sea buckthorn juice power is in pure orange for natural product needs of customers.

As the best raw material of sea buckthorn drinking, general sea buckthorn juice power is made from sea buckthorn fruit. It is a loose fine power in yellow or orange with seabuckthorn fruit inherent aroma and taste and no off-flavor. sea buckthorn juice power is easy in storage, delivery and use. It is rich in nutrients, only one gram of sea buckthorn juice power can reach seabuckthorn acid content of 100 mg. Therefore, it is widely used in various types of foods, strengthening the nutritional function of trace elements, vitamins, amino acids, and natual fruit acid etc. After long-term absorption of sea buckthorn juice power the effects of conditioning intestines and stomach, physical fitness improvement, beauty, as well as the treatment of some chronic diseases will be achieved.

The taste and nutrients of sea buckthorn juice are maintained in the production of sea buckthorn juice power. Adding water, it can be easily dissolved, the sea buckthorn juice will be restored for the processing of solid drink use. Mixing evenly the sea buckthorn juice power with a certain ratio of sweeteners, the instant Tang drink will be integrated. The unique fruit sour taste of sea buckthorn juice power helps it become the food additives of cookies and bread.

The production process of sea buckthorn juice power is as follows:

Astragalus Extract: Improve Your Immunity

Astragalus extract is the concentrated dry powder purified by water from the dry root and rhizome of legumes. The main active ingredients include astragaloside (0.0% -10%), Astragalus polysaccharides (20-50%), and Calycosin-7-glucoside (0.01% -5%). The Pharmacopoeia shows that Astragalus extract has the the efficacy of nourish vitality and invigorating splentic yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, and regenerating boday fluid and nourishing blood. At present, the active ingredients of astragaloside has attracted global attention.

Production Process:

Dig it in spring and autumn, remove the fibrous root and root apex and dry it, add solvent at 80 centigrade and extract it for 3 times, filtrate it, concentrate the filtrate at 70 centigrade to clear paste with the relative density of 1.18 to 1.22 (50 centigrade ), spray dry, then the Astragalus polysaccharide will be obtained. For high content of astragaloside, the purification, refinement and other processes will be needed.

Main efficacy:

1.For immune system:

Astragalus extract can improve the body immunity and has the two-way regulation: recover the body when the immune function is too low and suppress the body when the the immune function is too high, keeping the body in physiological balance.

2. For cardiovascular disease:

Astragalus saponin has cardiac effect of enhancing the cardiomyocyte lactate dehydrogenase and succinate dehydrogenase content. The experiments show that astragaloside can significantly improve the heart contractility of myocardial infarction and improve coronary flow with a protective effect on cardiac function.

Astragalus extract has the effect of dilating blood vessels and coronary arteries. Astragalus extract can promote vascular endothelial cell migration and added value in varying degree and accelerate the process of angiogenesis.

3.Anti-aging:

Astragalus extract can prevent senile arteriosclerosis and improve the lung function of aging. Studies have shown that astragalus extract has the good effect of life extension. It is worth of high attention and development as a anti-aging drug.

4. For the urinary system

Astragalus extract has the mild diuretic effect of inhibiting nephritis and reducing renal lesion by significantly reduce the amount of protein in the urine.

5.For liver function

Astragalus extract can protect the liver and prevent hepatic glycogen reduction, deducing the liver injury. Astragaloside is the effective component of anti-hepatotoxic injury of astragalus extract.

6. Antiviral effect

Astragalus extract can promote virus-induced and self-induced interferon. It has broad-spectrum antiviral effect with a significant confrontation of influenza virus, sindbis virus, and coxsackie virus etc.

7.For cerebrovascular diseases

Astragalus extract can dilate the brain blood vessels, increase cerebral blood flow, improve cerebral microcirculation, reduce blood viscosity, reduce platelet aggregation, enhance red blood cell deformability, remove free radical antioxidant, and enhance brain cell anoxia tolerance capacity. Regulate blood pressure and decrease brain edema, protecting brain cells and enhancing the repair function of damaged brain cells.

The application of astragalus extract

Astragalus extract has been use in healthy care and medicines. It is used as tincture and capsules/tablets according to the instructions of manufacturers. Pincredit provide domestic and international health care manufacturing enterprises with high-quality astragalus extract.

Notice for taking astragalus extract:

1.Because Astragalus extract can increase the effect of certain antiviral drugs. People taking this medicine should consult a doctor before using.

2.Astragalus extract may interfere with the immune system suppressants that are prescribed to people who receive organ transplants, so it should not be used by these patients.

3.Because of its anticoagulant activity, Astragalus extract may increase the risk of bleeding by taking a thinner of blood, such as coumarin. Do not take surgery before or after, as it may increase bleeding for people taking blood thinners such as Coumadin. Do not take before or after surgery as it could increase bleeding.

4.Astragalus extract is not recommended when there is acute diarrhea; it is not a problem if there is chronic mild diarrhea.

5.Taking large concentrated amounts for a prolonged period, in the form of extracts or capsules, may cause abdominal and chest tension in some people.

Efficacy and Taking Methods of Pine Pollen Disruption Powder

Pine pollen disruption powder is from the dried pollen of pinaceae plant pinus massoniana, pinus tabulaeformis or several types of plant from the same specie. In spring, pick up the spicas when the flower is just blooming, dry them, remove impurities, rough sieve, dehumidify pollen, breaking the pollen cell wall, and fine sieves, then pine pollen disruption powder will be obtained.

The study of pine pollen powder revealed after breaking the cell wall of natural pine pollen, nutrients could be released as the hard and indigestible airbag on the surface is broken. Therefore it is more faster to absorb pine pollen disruption powder with higher absorption rate.  

After the cell wall is broken, the pine pollen powder has poorer flow and bitter taste. Put it into a cup of water, it is suspending in the water after mixing, rarely floating and rarely sinking. If there is too much precipitation at the bottom of the cup, it indicates the pine pollen disruption powder contains a lot of impurities. The pine pollen powder is light yellow fine powder, aloft on the breeze, easy to fly apart, with a sense of lubrication by hand twist and fluid properties. After the cell wall is broken, the physical properties are changed with, loss of fluid properties and strong adhesion.

Pine pollen powder has the following effects:

1.Anti-fatigue. Pine pollen powder is an efficient functional health food. It can fully conditioning various systems of the human body for benefiting human health.
2.Anti-aging. Pine pollen powder contains a large number of antioxidants, such as vitamin E, carotene and trace element selenium etc, which can inhibit the body lipid and protein peroxidation rate, playing a role in anti-aging.
3.Skin care and beauty.
Pine pollen powder not only has a unique regulation of physiological function, but also has the special effects of keeping skin white, glowing and bodybuilding through promoting skin cell metabolism, delaying skin cell aging and increasing skin elasticity. Therefore, pine pollen powder is known as “eatable cosmetics”. Pine pollen powder contains both the abundant amino acids that can be directly absorbed by skin cells, and all the natural vitamins and various enzymes needed by skin cells, offering a basis for comprehensive beauty. Especially the vitamin C, E and B in the pine pollen powder coordinate to activate the cells, maintaining a high value of SOD in the body, removing the free radicals better, blocking the generation of chloasma, eliminating the skin of melanin, and keeping skin white and beautiful. In addition, pine pollen have a better effect of removing acne.
4.Liver protection. Pine pollen powder can promote liver cell activity, realizing normal bile secretion, preventing the occurrence of liver disease, and enhancing liver function.
5.Cardiovascular care. With its pure natural nutrition, Pine pollen powder strengthens the metabolism, regulates the endocrine glands, mobilizes the alternative excretion, meanwhile, it improves the heart, blood, blood vessels, play a role in cardiovascular health care.

Ways of eating pine pollen
You can make tea with pin pollen powder, put some sugar or milk powder with pine pollen etc. Or buy rice dumplings, cook them, dry them, roll pine pollen on the dumplings.

Tips for taking pine pollen powder:
1.Do not use water at high temperature, so as not to damage the active material. The water temperature should not exceed 40 centigrade.
2.Store pine pollen powder in a cool and dry place. Once the product is open, try to finish it on time.
3.Pine pollen powder is a health care product as both medicine and food. The working effect time is different due to various illness.
4.Non-toxic side effects, you can adhere to a long-term use. Seldom people may have conditioning reaction in the first one or two days of taking pine pollen powder, such as rash, local pain, etc, indicating it is at work of discharging the toxins in the body. Don’t worry, keep taking it.
5. For those who are troubled by freckles, acne and liver disease, taking pine pollen powder and vitamin C together has a good effect.

Extraction Method and Selection of Gynostemma Pentaphyllum Extract

Fresh Gynostemma Material

1.Extraction method and application of Gynostemma 

Extraction method

Soak in 10 times amount of 75% thyl alcohol for 12 hours, adopt ultrasonic extraction for three times and 80 minutes each time.

Research and application

Chinese medicine believes that Gynostemma, bitter in flavor and cold in property, has the effects of clearing heat and removing toxicity, nourishing vitality, relieving cough, and eliminating phlegm. The modern pharmacological studies show that Gynostemma is helpful for reducing blood fat, lowering blood pressure, increasing coronary and cerebral blood flow, anti-aging, keeping robust, enhancing immunity, liver protection, sedative analgesic, and anti-ulter etc and is significantly effective in the treatment of many diseases, such as the prevention and cure of atherosclerosis, hypertension, coronary Heart disease, stroke, diabetes, obesity, chronic hepatitis, chronic atrophic gastritis, chronic cholecystitis, ulcer disease, and bronchitis etc.

  Gynostemma as herb

In addition, Gynostemma is effective in anti-inflammatory role of detoxification, cough suppressant and expectorant. It is clinically used mainly for chronic bronchitis. It is also has campatibility with other traditional Chinese medicine with wide applications of hypolipidemic,immune enhancement and anti-cancer, and anti-aging etc. The current studied and developed Gynostemma prescription formulations mainly include the following formulations: tablets, granules, mixture, oral liquid, capsules, injections and so on.

As many Chinese people have a long-term habit of drinking Gynostemma tea, many factories in China are in the production of Gynostemma health drinks and the enterprises of extracting gypenosides are in small amount, while in recent year, the new drugs for lowering blood fact and curing cardiovascular diseases have been successfully developed.

2.Selection and drinking methods of Gynostemma

The selection of Gynostemma

The rhizome and whole herb of Gynostemma are used as the medicine, bitter in flavor and cold in property, with the functions of anti-inflammatory role of detoxification, cough suppressant and expectorant, lowering blood fat and cholesterol, anti-aging, strengthening spleen, anti-arteriosclerosis, and the treatment of young in white hair, chronic bronchitis, and gastric ulcer etc. The foods using Gynostemma as a additive is a new green food for nutrient nourishing, health and physical, disease prevention and treatment.

China is rich in resources of Gynostemma. It is reported that about 11 species of plants are easy to be confused with Gynostemma, including 7 type of Cucurbitaceae plants, especially Japanese Cayratia Herb. So when buying Gynostemma, you should seriously identify the authenticity.

When buying, you should see more and compare more, especially for the active ingredients. See if it has the specific data indicators. Secondly, wild Gynostemma is not better than artificial cultivation ones, you should attention to that. According to the data of research, different species of Gynostemma in various growing environment from different positions have different saponin level. The saponin content of Gynostemma in introduction and cultivation is higher than that of Gynostemma in wild herb and Ginsenoside content and amino acid content of Gynostemma in introduction and cultivation is higher than that of Gynostemma in wild herb. Because the purpose of artificial development is for improving the active ingredients of Gynostemma to better benefit human health.

The drinking method of Gynostemma:

1)The water is boiled. The saponin contained in Gynostemma is high in melting point which is dissolved at temperature of 80 degree centigrade.

2)Do not discard the first tea. The Gynostemma is different from traditional tea. The first tea kept bubbling up, and the bubbles are saponin. The total amount of saponin contained in Gynostemma is 4 times over that contained in ginseng. The saponin has not only the role of ginseng but also has another effect, clearing heat and removing toxicity with out the side effect of over use. So if you discard the first cup of tea, it is a super waste. And the saponins has been a monopoly of businessmen in Hangzhou.

3)Try to soak the active ingredients of Gynostemma tea. The authors of Japan and Japan have done a lot of researches on the chemical composition and structure of Gynostemma pentaphyllum. The studies show that in addition to Gypenoside, Gynostemma also contains active ingredients like flavonoids, polysaccharides, phospholipids, amino acids, vitamins, constants and and trace inorganic elements etc. So a bag of tea is best to drink for one day so as to fully release the active ingredients in Gynostemma.

Production Processes of Hawthorn Extract

Hawthorn leave extract is extracted from many production processes. Hawthorn leave extract is from the ethanol extract of dry hawthorn leaves and its main active ingredient is hawthorn leaves flavonoids (HLF). Hawthorn leave extract is applied in health food for regulating blood lipids. According to the 2015 edition of China Pharmacopoeia, hawthorn leave extract have the effects of activating circulation to remove blood stasis, regulating the flow of vital energy for promoting blood circulation, lowering lipid and for the treatment of stagnation of vital energy and blood stasis, thoracic obstruction and cardialgia, chest oppression and breath obstruction, palpitations and forgetfulness, dizziness and tinnitus, and hyperlipidemia. The flavonoids of hawthorn leaves has a significant effect on the heart and cerebrovascular system.

Production processes: Hawthorn leave extract is made from dry leaves of Rosaceae plant large-fruited Chinese hawthorns or hawthorns. Harvest the hawthorn leaves in summer and autumn, airing them, shatter them into coarse powder; Input the raw materials into the pot then add 50%  ethyl alcohol and extract the material twice and 2 hours each time at the temperature of 50℃ to 60℃ (adding 10 times amount of 50% ethyl alcohol for the first time, adding 8 times amount of 50% ethyl alcohol for the second time ), filtering, merging filtrates, recycling ethyl alcohol to collect filtrates without alcohol taste, diluting with the same amount of water, eluting successively with the following of water and different concentrations of ethanol through D101 macroporous adsorption resin column to collect he corresponding eluent, recycling ethanol, concentrating to the clear paste with relative density of about 1.10 ( at the temperature of 60 ℃) and spray drying, then production processes of the hawthorn leave extract are completed. For high content, extraction, chromatography, crystallization and other extra processes are required.

Xi'an Pincredit Bio-Tech Co., Ltd. has been dedicating to the development and production of natural plant extraction for years. Our products are targeted docking auxiliary hypoglycemic and hypolipidemic health food manufacturing enterprises. Xi'an Pincredit Bio-Tech Co., Ltd. is one of the best suppliers with stable supply and reliable quality.